Cat. No.: DAB-0012178
| Product Information | |
|---|---|
| Clonality | Monoclonal |
| Isotype | IgG |
| Host Species | Rabbit |
| Reactivity | Human |
| Applications | WB, IP, IHC |
| Product Description | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asn773 of human INPP4b protein. |
| Format | Liquid |
| Purity | Affinity purity |
| Target Information | |
|---|---|
| Target Name | INPP4B |
| UniProt No. | O15327 |
| Gene ID | 8821 |
| Gene Description | Phosphatidylinositol lipids and phosphoinositides are important second messengers, their generation controlling many cellular events. Intracellular levels of these molecules are regulated by phosphoinositide kinases and phosphatases. One of the best characterized lipid kinases is phosphoinositide 3-kinase, which is responsible for phosphorylation on the D-3 position of the inositide head group. This action of PI3K catalyzes the production of phosphatidylinositol-3, 4, 5-triphosphate by phosphorylating phosphatidylinositol, phosphatidylinositol-4-phosphate, and phosphatidylinositol-4, 5-bisphosphate. Growth factors and hormones trigger this phosphorylation event, which in turn coordinates cell growth, cell cycle entry, cell migration, and cell survival. PTEN, the well characterized partnering phosphatase, reverses this process by removing the phosphate from PIP3 at the D-3 position to generate PIP2. Dephosphorylation on the D-5 position to generate PIP2 occurs through the action of SHIP1 or SHIP2, and dephosphorylation on the D-4 position to generate PIP can occur through the action of inositol polyphosphate 4-phosphatase isoenzymes type I and type II. While INPP4a has been implicated in neuronal survival and megakaryocyte lineage determination, less is understood about INPP4b. It has been shown that two splice variants of INPP4b occur in mice, each showing distinct tissue distribution and subcellular localization. |
| Shipping & Storage | |
|---|---|
| Shipping | Shipped at 4 °C. |
| Storage Instructions | Store at –20 °C. Do not aliquot the antibody. |
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. |
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