Rabbit IGFBP5 (E3H3Z) Monoclonal Antibody

Rabbit IGFBP5 (E3H3Z) Monoclonal Antibody

Cat. No.: DAB-0012163

Size: 20 µL Size: 100 µL Size: Customer Size
Product Information
Clonality Monoclonal
Isotype IgG
Host Species Rabbit
Reactivity Human
Applications WB, IF
Product Description Monoclonal antibody is produced by immunizing animals with recombinant protein specific to human IGFBP5 protein.
Format Liquid
Purity Affinity purity
Target Information
Target Name IGFBP5
UniProt No. P24593
Gene ID 3488
Gene Description Insulin-like growth factor signaling plays a major role in regulating the proliferation and metabolism of normal and malignant cells. IGF-binding proteins play an integral role in modifying IGF actions in a wide variety of cell types. The six IGFBP family members share a high affinity for IGF binding and are structurally related, but are encoded by distinct genes. IGFBPs can exert stimulatory or inhibitory effects by controlling IGF availability through high affinity binding of IGF at the carboxy-terminal domain. IGFBP5 belongs to the high affinity IGF binding family. The effects of IGFBP5 on cancer development are either positive or negative depending on the cancer type. IGFBP5 has been shown to regulate tumor cell survival, apoptosis, migration, and metastasis by mechanism of IGF-dependent or IGF-independent actions. Downregulation of IGFBP5 is associated with therapeutic resistance in breast cancer and esophageal carcinoma. Meanwhile, upregulation of the protein can reverse drug resistance.
Shipping & Storage
Shipping Shipped at 4 °C.
Storage Instructions Store at –20 °C. Do not aliquot the antibody.
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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