Rabbit IGF-I Receptor β (phospho Tyr1135/1136)/Insulin Receptor β (phospho Tyr1150/1151) (19H7) Monoclonal Antibody

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Cat. No.: DAB-0012524

Size: 20 µL Size: 100 µL Size: Customer Size

Product Information
Clonality	Monoclonal
Isotype	IgG
Host Species	Rabbit
Reactivity	Human, Mouse, Rat
Applications	WB
Product Description	Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr1135/1136 of human IGF-I receptor β.
Format	Liquid
Purity	Affinity purity

Target Information
Gene Description	Type I insulin-like growth factor receptor is a transmembrane receptor tyrosine kinase that is widely expressed in many cell lines and cell types within fetal and postnatal tissues. Receptor autophosphorylation follows binding of the IGF-I and IGF-II ligands. Three tyrosine residues within the kinase domain are the earliest major autophosphorylation sites. Phosphorylation of these three tyrosine residues is necessary for kinase activation. Insulin receptors share significant structural and functional similarity with IGF-I receptors, including the presence of an equivalent tyrosine cluster within the kinase domain activation loop. Tyrosine autophosphorylation of IRs is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation at Tyr1146 and either Tyr1150 or Tyr1151, while full kinase activation requires triple tyrosine phosphorylation.

Target Information

Gene Description

Type I insulin-like growth factor receptor is a transmembrane receptor tyrosine kinase that is widely expressed in many cell lines and cell types within fetal and postnatal tissues. Receptor autophosphorylation follows binding of the IGF-I and IGF-II ligands. Three tyrosine residues within the kinase domain are the earliest major autophosphorylation sites. Phosphorylation of these three tyrosine residues is necessary for kinase activation. Insulin receptors share significant structural and functional similarity with IGF-I receptors, including the presence of an equivalent tyrosine cluster within the kinase domain activation loop. Tyrosine autophosphorylation of IRs is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation at Tyr1146 and either Tyr1150 or Tyr1151, while full kinase activation requires triple tyrosine phosphorylation.

Shipping & Storage
Shipping	Shipped at 4 °C.
Storage Instructions	Store at –20 °C. Do not aliquot the antibody.
Storage Buffer	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

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