Rabbit IDH2 (D8E3B) Monoclonal Antibody

Rabbit IDH2 (D8E3B) Monoclonal Antibody

Cat. No.: DAB-0012156

Size: 20 µL Size: 100 µL Size: Customer Size
Product Information
Clonality Monoclonal
Isotype IgG
Host Species Rabbit
Reactivity Human, Mouse, Rat
Applications WB, IP, IHC
Product Description Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val195 of human IDH2 protein.
Format Liquid
Purity Affinity purity
Target Information
Target Name IDH2
UniProt No. P48735
Gene ID 3418
Gene Description IDH2 is one of three isocitrate dehydrogenases that catalyze the oxidative decarboxylation of isocitrate to produce CO2 and α-ketoglutarate. These enzymes belong to two distinct subclasses that utilize either NAD or NADP+ as an electron acceptor. IDH2 is an NADP+-dependent isocitrate dehydrogenase expressed primarily in the mitochondria, where it also functions in the TCA cycle. Mutations in IDH2 or its cytoplasmic counterpart have been reported in glioblastoma multiforme, acute myeloid leukemia, and other malignancies. Research studies have shown that gain-of-function mutations in IDH2 can lead to the accumulation and secretion of the oncometabolite R-2-hydroxyglutarate in cancer cells.
Shipping & Storage
Shipping Shipped at 4 °C.
Storage Instructions Store at –20 °C. Do not aliquot the antibody.
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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