Rabbit HRP FOXA2 Monoclonal Antibody

Rabbit HRP FOXA2 Monoclonal Antibody

Cat. No.: DAB-0011222

Size: 20 µL Size: 100 µL Size: Customer Size
Product Information
Clonality Monoclonal
Isotype IgG
Host Species Rabbit
Reactivity Human, Mouse, Rat
Applications WB
Product Description HRP Rabbit monoclonal antibody [EPR4466] to FOXA2.
Format Liquid
Purity Affinity purity
Target Information
Target Name FOXA2
UniProt No. Q9Y261
Gene ID 3170
Gene Description Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3'. In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
Shipping & Storage
Shipping Shipped at 4 °C.
Storage Instructions Store at +4 °C short term (1-2 weeks). Upon delivery aliquot. Store at -20 °C. Avoid freeze / thaw cycle. Store In the Dark.
Storage Buffer pH: 7.40; Preservative: 0.1% Proclin 300 Solution; Constituents: 30% Glycerol (glycerin, glycerine), 1% BSA, PBS
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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