Rabbit HIF-2α (E2N9W) Monoclonal Antibody

Rabbit HIF-2α (E2N9W) Monoclonal Antibody

Cat. No.: DAB-0012127

Size: 20 µL Size: 100 µL Size: Customer Size
Product Information
Clonality Monoclonal
Isotype IgG
Host Species Rabbit
Reactivity Mouse, Rat
Applications WB, IP
Product Description Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of mouse HIF-2α protein.
Format Liquid
Purity Affinity purity
Target Information
Target Name Epas1
UniProt No. P97481
Gene ID 13819
Gene Description Hypoxia-inducible factor is essential for the cellular response to hypoxia., der normoxia conditions, the α subunit of HIF is ubiquitinated by von Hippel-Lindau protein and is degraded in the ubiquitin/proteasome pathway. Hypoxia inhibits degradation of the α subunit, which leads to its stabilization. HIF, in turn, regulates the transcription of a variety of genes that respond to hypoxia conditions. There are several isoforms of the HIF α subunit. Studies have found that HIF-1α and HIF-2α expression is increased in some human cancers. HIF-1α has both pro- and anti-proliferative activities, whereas HIF-2α does not possess anti-proliferative activity. Therefore, HIF-2α likely plays an important role in tumorigenesis.
Shipping & Storage
Shipping Shipped at 4 °C.
Storage Instructions Store at –20 °C. Do not aliquot the antibody.
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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