Cat. No.: DAB-0013043
Product Information | |
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Clonality | Polyclonal |
Isotype | IgG |
Host Species | Rabbit |
Reactivity | Human |
Product Description | KLH conjugated synthetic peptide between 76-105 amino acids from the N-terminal region of human GSK3 alpha. |
Format | Liquid |
Purity | Affinity purity |
Target Information | |
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Target Name | GSK3A |
UniProt No. | P49840 |
Gene ID | 2931 |
Gene Description | Glycogen synthase kinase-3 was initially identified as an enzyme that regulates glycogen synthesis in response to insulin. GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β. GSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development. GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization.~GSK-3α regulates the production of amyloid-β peptides, a major component of the plaques that accumulate with progression of Alzheimer disease. Administration of therapeutic concentrations of lithium, a GSK-3 inhibitor, attenuates amyloid-β production by specifically inhibiting the cleavage of amyloid precursor protein by γ-secretase, blocking accumulation of amyloid-β peptides in the brains of mice that overproduce APP. |
Shipping & Storage | |
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Shipping | Shipped at 4 °C. |
Storage Instructions | Store undiluted at -20 °C, avoiding repeated freeze thaw cycles. |
Storage Buffer | Phosphate buffered saline. 0.09% Sodium Azide (NaN3). |