Rabbit GSK3 β Monoclonal Antibody

Rabbit GSK3 β Monoclonal Antibody

Cat. No.: DAB-0010414

Size: 20 µL Size: 100 µL Size: Customer Size
Product Information
Clonality Monoclonal
Isotype IgG
Host Species Rabbit
Reactivity Human, Mouse
Applications ICC, IF
Product Description Rabbit monoclonal antibody [Y174] to GSK3 beta.
Format Liquid
Purity Affinity purity
Target Information
Target Name GSK3B
UniProt No. P49841
Gene ID 2932
Gene Description Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Phosphorylates MACF1 and this phosphorylation inhibits the binding of MACF1 to microtubules which is critical for its role in bulge stem cell migration and skin wound repair.
Shipping & Storage
Shipping Shipped at 4 °C.
Storage Instructions Store at +4 °C short term (1-2 weeks). Upon delivery aliquot. Store at -20 °C. Avoid freeze / thaw cycle. Store In the Dark.
Storage Buffer pH: 7.40; Preservative: 0.02% Sodium azide; Constituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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