Rabbit GLDC Polyclonal Antibody

Rabbit GLDC Polyclonal Antibody

Cat. No.: DAB-0012064

Size: 20 µL Size: 100 µL Size: Customer Size
Product Information
Clonality Polyclonal
Host Species Rabbit
Reactivity Human, Mouse, Rat, Monkey
Applications WB
Product Description Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val668 of human GLDC protein. Antibodies are purified by protein A and peptide affinity chromatography.
Format Liquid
Purity Affinity purity
Target Information
Target Name GLDC
UniProt No. P23378
Gene ID 2731
Gene Description Glycine decarboxylase is a component of a mitochondrial protein complex that catalyzes the degradation of glycine. The glycine cleavage system is composed of three distinct enzymes and an additional component that transfers a glycine methylamine group from one enzyme to another. The GLDC protein is the decarboxylase that binds the methylamine group for transfer to the T-protein. Tumor-initiating cells in the primary non-small cell lung cancer express high levels of GLDC and LIN28B, both of which are essential for the proliferation of tumor-initiating cells. GLDC is an oncogene that promotes tumorigenesis through its metabolic activity. Mutations in the corresponding GLDC gene account for the majority of reported cases of glycine encephalopathy, which is a metabolic disorder characterized by the accumulation of glycine, lethargy, hypotonia, intractable seizures, and death.
Shipping & Storage
Shipping Shipped at 4 °C.
Storage Instructions Store at –20 °C. Do not aliquot the antibody.
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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