Rabbit GFAT1 (D12F4) Monoclonal Antibody

Rabbit GFAT1 (D12F4) Monoclonal Antibody

Cat. No.: DAB-0012059

Size: 20 µL Size: 100 µL Size: Customer Size
Product Information
Clonality Monoclonal
Isotype IgG
Host Species Rabbit
Reactivity Human, Rat
Applications WB, IP
Product Description Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the sequence around Gly100 of human GFAT1.
Format Liquid
Purity Affinity purity
Target Information
Target Name GFPT1
UniProt No. Q06210
Gene ID 2673
Gene Description GFAT1, glutamine:fructose-6-phosphate aminotransferase 1, is the rate-limiting enzyme of the hexosamine biosynthesis pathway. This enzyme catalyzes the conversion of fructose-6-phosphate and glutamine to glucosamine-6-phosphate and glutamate. The hexosamine biosynthesis pathway generates the building blocks for protein and lipid glycosylation. Furthermore, studies suggest that increased activity of this pathway is a contributing factor to hyperglycemia-induced insulin resistance. GFAT1 is more active in non-insulin-dependent diabetes mellitus patients. Transgenice mice overexpressing this enzyme in skeletal muscle and adipose tissue show an insulin resistance phenotype. GFAT2, an isoenzyme of GFAT1, was later identified. Studies show that the regulation of GFAT2 is different from that of GFAT1, suggesting differential regulation of the hexosamine pathway in different tissues.
Shipping & Storage
Shipping Shipped at 4 °C.
Storage Instructions Store at –20 °C. Do not aliquot the antibody.
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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