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Cat. No.: DAB-0013044
| Product Information | |
|---|---|
| Clonality | Polyclonal |
| Isotype | IgG |
| Host Species | Rabbit |
| Reactivity | Human |
| Product Description | Synthetic peptide corresponding to a portion of the amino acid sequence between 600-673 of human FOXO3A – KLH conjugated. |
| Format | Liquid |
| Purity | Affinity purity |
| Target Information | |
|---|---|
| Target Name | FOXO3 |
| UniProt No. | O43524 |
| Gene ID | 2309 |
| Gene Description | The Forkhead family of transcription factors is involved in tumorigenesis of rhabdomyosarcoma and acute leukemias. Within the family, three members have sequence similarity to the nematode orthologue DAF-16, which mediates signaling via a pathway involving IGFR1, PI3K, and Akt. Active forkhead members act as tumor suppressors by promoting cell cycle arrest and apoptosis. Increased expression of any FoxO member results in the activation of the cell cycle inhibitor p27 Kip1. Forkhead transcription factors also play a part in TGF-β-mediated upregulation of p21 Cip1, a process negatively regulated through PI3K. Increased proliferation results when forkhead transcription factors are inactivated through phosphorylation by Akt at Thr24, Ser256, and Ser319, which results in nuclear export and inhibition of transcription factor activity. Forkhead transcription factors can also be inhibited by the deacetylase sirtuin . |
| Shipping & Storage | |
|---|---|
| Shipping | Shipped at 4 °C. |
| Storage Instructions | This product is shipped at ambient temperature. It is recommended to aliquot and store at -20 °C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8 °C for short term use (up to 4 weeks) and store the remaining aliquots at -20 °C. Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. |
| Storage Buffer | Phosphate buffered saline <0.1% Sodium Azide (NaN3)0.5% Bovine Serum Albumin |
Ace Therapeutics has a team of experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
