Cat. No.: DAB-0012027
| Product Information | |
|---|---|
| Clonality | Monoclonal |
| Isotype | IgG |
| Host Species | Rabbit |
| Reactivity | Human |
| Applications | WB |
| Product Description | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu278 of human FoxC2 protein. |
| Format | Liquid |
| Purity | Affinity purity |
| Target Information | |
|---|---|
| Target Name | FOXC2 |
| UniProt No. | Q99958 |
| Gene ID | 2303 |
| Gene Description | Forkhead box proteins are a family of evolutionarily conserved transcription factors defined by the presence of a winged helix DNA binding domain called a Forkhead box. In humans, there are over 40 known Fox protein family members, divided into 19 subfamilies, which have evolved to regulate gene transcription in diverse and highly specialized biological contexts throughout development. Mutations that disrupt the expression of Fox gene family members have consequently been implicated in a broad array of human disorders, including immunological dysfunction, infertility, speech/language disorders, and cancer.The expression of FoxC2 and several other Fox transcription factors are regulated during adipogenesis, suggesting their involvement in adipocyte differentiation. A transgenic mouse model exhibiting over expression of FoxC2 in white adipose tissue and brown adipose tissue showed a reduction of the intra-abdominal WAT depot. The BAT-specific gene Ucp1 is upregulated in the intra-abdominal WAT depot of these transgenic mice, resulting in histological features similar to those seen in BAT. This evidence suggests that FoxC2 can play a protective role against obesity and diet-induced insulin resistance. |
| Shipping & Storage | |
|---|---|
| Shipping | Shipped at 4 °C. |
| Storage Instructions | Store at –20 °C. Do not aliquot the antibody. |
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. |
Ace Therapeutics has a team of wellknown experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
