Cat. No.: DAB-0011945
| Product Information | |
|---|---|
| Clonality | Monoclonal |
| Isotype | IgG |
| Host Species | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| Product Description | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro298 of human cystathionine γ-lyase protein. |
| Format | Liquid |
| Purity | Affinity purity |
| Target Information | |
|---|---|
| Target Name | CTH |
| UniProt No. | P32929 |
| Gene ID | 1491 |
| Gene Description | Cystathionine γ-lyase is an enzyme in the transsulfuration pathway, a route in the metabolism of sulfur-containing amino acids. This enzyme regulates local vasodilation and blood pressure by generating hydrogen sulfide as a physiological signaling molecule. A rodent model of sleep apnea showed that H2S production by cystathionine γ-lyase in the carotid body triggers hypertension in rodents during intermittent hypoxia, suggesting that inhibition of this enzyme may prevent the hypertension associated with sleep apnea. In addition, dietary restriction of sulfur-containing amino acids upregulates hepatic cystathionine γ-lyase expression in mice, leading to elevated production of H2S and protection from hepatic ischemia perfusion injury, indicating that this enzyme is critical for the benefits of dietary restriction. |
| Shipping & Storage | |
|---|---|
| Shipping | Shipped at 4 °C. |
| Storage Instructions | Store at –20 °C. Do not aliquot the antibody. |
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. |
Ace Therapeutics has a team of wellknown experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
