x
- Home
- About Diabetes
- Services
- Diabetes Mellitus Modeling Solutions
- R&D Services for Diabetes Mellitus and Diabetic Complications
- By Drug Development Process
- About Us
- Careers
- Contact Us
Cat. No.: DAB-0011905
| Product Information | |
|---|---|
| Clonality | Monoclonal |
| Isotype | IgG |
| Host Species | Rabbit |
| Reactivity | Human, Mouse, Rat, Monkey |
| Applications | WB, IP |
| Product Description | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding His111 of human CLIC4 protein. |
| Format | Liquid |
| Purity | Affinity purity |
| Target Information | |
|---|---|
| Target Name | CLIC4 |
| UniProt No. | Q9Y696 |
| Gene ID | 25932 |
| Gene Description | Chloride intracellular channel proteins belong to a family of highly conserved transport proteins found as both soluble and membrane-bound forms. Although CLIC proteins have putative, selective chloride ion channel activity, they are structural homologs to members of the glutathione-S-transferase protein superfamily and are likewise regulated by redox status. CLIC proteins are distinct from other ion channels in that they are found as both soluble and integral membrane forms, and their form determines their function. Chloride intracellular channel proteins are ubiquitously expressed in numerous tissue types and are involved in diverse biological functions.Chloride intracellular channel 4 is a well-studied member of the chloride intracellular channel family. Expression of CLIC4 is regulated by p53 and c-Myc, and CLIC4 is required for p53 and c-Myc-mediated apoptosis in some cell types. CLIC4 contributes to TNF-α mediated apoptosis independent of NF-κB. Moreover, CLIC4 regulates the maturation of keratinocytes, differentiation of adipocytes and blood vessel lumen formation. Research studies show that CLIC4 translocates from the cytoplasm to the nucleus in response to cellular stress. In addition, nuclear CLIC4 enhances TGF-β signaling. In human cancer tissues, CLIC4 is excluded from the nucleus of tumor cells and its expression is reduced in tumor epithelial tissues; conversely, CLIC4 expression is markedly elevated in the adjacent stroma of multiple human cancers. Researchers have shown that high stromal CLIC4 protein levels enhance tumor invasiveness and progression. |
| Shipping & Storage | |
|---|---|
| Shipping | Shipped at 4 °C. |
| Storage Instructions | Store at –20 °C. Do not aliquot the antibody. |
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. |
Ace Therapeutics has a team of wellknown experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
