Cat. No.: DAB-0011904
Product Information | |
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Clonality | Monoclonal |
Isotype | IgG |
Host Species | Rabbit |
Reactivity | Human, Mouse, Rat, Hamster, Monkey |
Applications | WB, IF |
Product Description | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human citrate synthase protein. |
Format | Liquid |
Purity | Affinity purity |
Target Information | |
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Target Name | CS |
UniProt No. | O75390 |
Gene ID | 1431 |
Gene Description | Citrate synthase is a mitochondrial enzyme that catalyzes the first and rate-limiting reaction of the citric acid cycle. The enzyme is responsible for the conversion of oxaloacetate and acetyl-CoA to citrate and CoA. Research studies show that CS knockdown HeLa cells are more malignant than vector-transfected cells from an in vivo xenograft model, which suggests a direct link between the Warburg Effect and tumor growth. Intervertebral disc degeneration, a growing health problem, has been linked to changes in citrate synthase activity. |
Shipping & Storage | |
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Shipping | Shipped at 4 °C. |
Storage Instructions | Store at –20 °C. Do not aliquot the antibody. |
Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. |