Cat. No.: DAB-0011900
| Product Information | |
|---|---|
| Clonality | Monoclonal |
| Isotype | IgG |
| Host Species | Rabbit |
| Reactivity | Human, Mouse, Rat, Hamster, Monkey, Bovine |
| Applications | WB |
| Product Description | Monoclonal antibody is produced by immunizing animals with recombinant mouse MBP-chronophin. |
| Format | Liquid |
| Purity | Affinity purity |
| Target Information | |
|---|---|
| Target Name | PDXP |
| UniProt No. | Q96GD0 |
| Gene ID | 57026 |
| Gene Description | Cofilin is a conserved actin-severing protein required for processes that rely on actin dynamics, including cytokinesis and cell motility. Regulation of actin dynamics requires the controlled cycling between the phosphorylated and unphosphorylated forms of cofilin. The severing activity of cofilin is inhibited by LIMK or TESK phosphorylation at the conserved amino-terminal Ser3 of cofilin. Slingshot phosphatase, for which there have been three mammalian isoforms identified, dephosphorylates cofilin in vivo. Chronophin is a haloacid dehalogenase phosphatase that also dephosphorylates cofilin. Alteration of CIN activity through overexpression of either the wildtype or phosphatase-inactive mutant CIN interferes with actin dynamics, cell morphology and cytokinesis. |
| Shipping & Storage | |
|---|---|
| Shipping | Shipped at 4 °C. |
| Storage Instructions | Store at –20 °C. Do not aliquot the antibody. |
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. |
Ace Therapeutics has a team of wellknown experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
