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Cat. No.: DAB-0011864
| Product Information | |
|---|---|
| Clonality | Polyclonal |
| Host Species | Rabbit |
| Reactivity | Human |
| Applications | WB, IP |
| Product Description | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys169 of human CA2 protein. Antibodies are purified by protein A and peptide affinity chromatography. |
| Format | Liquid |
| Purity | Affinity purity |
| Target Information | |
|---|---|
| Target Name | CA2 |
| UniProt No. | P00918 |
| Gene ID | 760 |
| Gene Description | Carbonic anhydrases are a family of ancient zinc metalloenzymes found in almost all living organisms. All CA can be divided into 3 distinct classes that evolved independently and have no significant homology in sequence and overall folding. All functional CA catalyze the reversible hydration of CO2 into HCO3- and H+ and contain a zinc atom in the active sites essential for catalysis. There are many isoforms of CA in mammals and they all belong to the α class.CA2 is a cytosolic member of the α class. It is the most widely distributed isoform among the mammalian CAs. Defects in CA2 are associated with osteopetrosis and renal tubular acidosis. Elevated expression of CA2 is observed in patients with Alzheimer’s disease and the developing brains of Down syndrome patients. CA2 is also overexpressed in Gastrointestinal Stromal Tumors and is considered a useful marker for diagnosis. Recently, CA2 was reported to facilitate transporter activity of the monocarboxylate transporter isoform 1 and 4 independent of its own catalytic activity |
| Shipping & Storage | |
|---|---|
| Shipping | Shipped at 4 °C. |
| Storage Instructions | Store at –20 °C. Do not aliquot the antibody. |
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. |
Ace Therapeutics has a team of wellknown experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
