Rabbit C17orf59 (D2B5X) Monoclonal Antibody

Rabbit C17orf59 (D2B5X) Monoclonal Antibody

Cat. No.: DAB-0011858

Size: 20 µL Size: 100 µL Size: Customer Size
Product Information
Clonality Monoclonal
Isotype IgG
Host Species Rabbit
Reactivity Human, Monkey
Applications WB
Product Description Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu270 of human C17orf59 protein.
Format Liquid
Purity Affinity purity
Target Information
Target Name BORCS6
UniProt No. Q96GS4
Gene ID 54785
Gene Description mTORC1 kinase complex is a critical component to regulate cell growth in response to energy levels, growth factors, and amino acids. The GTPases RagA, RagB, RagC and RagD have been shown to interact with raptor in mTORC1. A Ragulator complex, consisting of LAMTOR1/C11orf59, LAMTOR2/ROBLD3, LAMTOR3/MAPKSP1, LAMTOR4/C7orf59 and LAMTOR5/HBXIP, associates with the Rag GTPases and recruit them to the surface of lysosomes. These interactions lead to mTORC1 activation in response to amino acid signals. In addition, C17orf59 was shown to interact with Ragulator and disrupt the interaction between Ragulator and Rag GTPases. This disruption prevents mTOR from localizing to the lysosomal membrane and therefore inhibits mTORC1 activation.
Shipping & Storage
Shipping Shipped at 4 °C.
Storage Instructions Store at –20 °C. Do not aliquot the antibody.
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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