Cat. No.: DAB-0011828
Product Information | |
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Clonality | Monoclonal |
Isotype | IgG |
Host Species | Rabbit |
Reactivity | Human, Monkey |
Applications | WB, IF |
Product Description | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the amino terminus of human Aurora A/AIK. |
Format | Liquid |
Purity | Affinity purity |
Target Information | |
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Target Name | AURKA |
UniProt No. | O14965 |
Gene ID | 6790 |
Gene Description | Aurora A is a cell cycle-regulated Ser/Thr protein kinase that is overexpressed in many tumor cell lines. Phosphorylation of Aurora A at Thr288 within the kinase activation loop results in a significant increase in its activity and may target the protein for proteasomal degradation during mitosis. The closely-related kinase Aurora B has been implicated in multiple mitotic events, and siRNA silencing of Aurora B expression results in reduced histone H3 phosphorylation, aberrant chromosome alignment/segregation, and altered survivin localization. |
Shipping & Storage | |
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Shipping | Shipped at 4 °C. |
Storage Instructions | Store at –20 °C. Do not aliquot the antibody. |
Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. |
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