Cat. No.: DAB-0011817
| Product Information | |
|---|---|
| Clonality | Polyclonal |
| Host Species | Rabbit |
| Reactivity | Human, Mouse, Rat, Monkey |
| Applications | WB |
| Product Description | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to a sequence around Leu32 of human ATP2A2/SERCA2. Antibodies are purified by protein A and peptide affinity chromatography. |
| Format | Liquid |
| Purity | Affinity purity |
| Target Information | |
|---|---|
| Target Name | ATP2A2 |
| UniProt No. | P16615 |
| Gene ID | 488 |
| Gene Description | The ATP2A2 calcium pump is one of several sarcoplasmic and endoplasmic reticulum Ca2+-ATPases responsible for regulating calcium transport across intracellular membranes. Multiple isoforms have been isolated, with ATP2A2a found predominantly in the sarcoplasmic reticulum of muscle cells and ATP2A2b more ubiquitously expressed in the endoplasmic reticulum of most cell types. An isoform containing a truncated carboxy region is expressed in epithelial and hematopoietic cell lines and may be involved in monocyte differentiation. Post-translational modification of ATP2A2, including phosphorylation and tyrosine nitration, modify Ca2+ -ATPase activity and calcium transport. Mutation in the corresponding ATP2A2 gene results in Darier disease, a skin disorder characterized by the presence of dark, keratotic papules or rash found on the head and torso. |
| Shipping & Storage | |
|---|---|
| Shipping | Shipped at 4 °C. |
| Storage Instructions | Store at –20 °C. Do not aliquot the antibody. |
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. |
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