Cat. No.: DAB-0011783
| Product Information | |
|---|---|
| Clonality | Polyclonal |
| Host Species | Rabbit |
| Reactivity | Human, Monkey |
| Applications | WB, IP |
| Product Description | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val185 of human Astrin/SPAG5 protein. Antibodies are purified by protein A and peptide affinity chromatography. |
| Format | Liquid |
| Purity | Affinity purity |
| Target Information | |
|---|---|
| Target Name | SPAG5 |
| UniProt No. | Q96R06 |
| Gene ID | 10615 |
| Gene Description | Astrin/SPAG5 was identified as a microtubule-associated protein in a mitotic extract. It is essential for cells to assemble biploar spindle structures and progress through mitosis. Astrin/SPAG5 was also identified to be a component associated with outer dense fibers in the sperm tail. In addition, this protein negatively regulates mTORC1 activity during the cell stress response., der stress conditions, Astrin/SPAG5 interacts with the mTORC1 component raptor and recruits raptor to stress granules, thereby suppressing mTORC1 formation. The inhibition of mTORC1 prevents its hyperactivation and thus keeps cells from undergoing apoptosis during stresses. Furthermore, Astrin/SPAG5 has been implicated to be a prognostic marker in breast cancer. |
| Shipping & Storage | |
|---|---|
| Shipping | Shipped at 4 °C. |
| Storage Instructions | Store at –20 °C. Do not aliquot the antibody. |
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. |
Ace Therapeutics has a team of wellknown experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
