In drug development, preclinical development usually includes in vitro and in vivo studies that provide detailed information needed for further development of the drug. Ace Therapeutics can provide the services related to preclinical development for diabetes drugs.

Overview of Preclinical Research

For preclinical development, an appropriate animal model that accurately reflects human pathological conditions is essential. Cell and molecular studies provide important mechanistic data and toxicity studies evaluate candidate drugs. Drugs may undergo pharmacology and toxicology testing. Pharmacology emphasizes the therapeutic effects of chemicals, whereas toxicology is the study of chemical's adverse effects and risk assessment.

• Small Molecules Drug Preclinical Studies
  Drugs may undergo pharmacology and toxicology testing. Pharmacology is closely related to toxicology, which including pharmacodynamics (PD) and pharmacokinetics (PK). Both pharmacology and toxicology are scientific disciplines that focus on understanding the properties and actions of chemicals.

Biofilm Lifestyle and Pharmacodynamics (Trubenová, B.; et al. Trends in Microbiology, 2022)

• Antibody Therapies Preclinical Studies
  Antibody-drug conjugates, bispecific antibodies and other novel antibodies have the advantages of high specificity, strong selectivity and non-cytotoxicity. However, the structure and function of such drugs are relatively complex, which brings special risks to safety. In the preclinical safety evaluation, it is necessary to establish a scientific evaluation scheme according to its characteristics and possible mediated toxicity mechanisms.

Our Services

Ace Therapeutics supports the evaluation of therapeutics of multiple forms, including small molecules and biomolecules. Our services include but not limited to the followings.

Features of Our Services

Ace Therapeutics can accelerate the therapeutic development and drug discovery process about diabetes for our clients worldwide. Our assays are developed and processed with the highest standard and the results are delivered on time without compromising quality. Please feel free to contact us.

References

1. Trubenová, B.; et al. Population genetics, biofilm recalcitrance, and antibiotic resistance evolution. Trends in Microbiology, 2022.
2. Premarathna, A. D.; et al. Preliminary screening of the aqueous extracts of twenty-three different seaweed species in Sri Lanka with in-vitro and in-vivo assays. Heliyon, 2020, 6(6), e03918.

• Target Identification Service
• Drug Discovery Service
• Lead Optimization Service

• Mouse Models
• Assay Kits
• Antibodies
• Cell Lines & Lysates
• Proteins & Peptides
• Inhibitors & Activators