In vitro cell models have become powerful tools for diabetes research, which can provide important molecular insights into diabetes. Ace Therapeutics offers multiple pancreatic islet cell models for pancreatic beta cell physiology research and in vitro drug testing, thus accelerating the drug development of diabetes.

Significance of Pancreatic Islet Cell Models

There are four types of functional secretory cells in the pancreas: beta cells, alpha cells, delta cells, and PP cells. Among them, beta cells, which take about 60% to 70%, are responsible for insulin secretion. Due to several factors, pancreatic beta-cell damage may lead to insufficient insulin secretion, which is an important mechanism leading to the development of diabetes. Thus, in vitro models of impaired islet cells are prepared to study the specific mechanism of diabetes. The commonly employed models are primary human and mouse pancreatic cells, cell lines obtained from pancreatic beta cell tumors, and the cell lines from transgenic mice expressing oncogenes directed to the pancreatic cells.

Fig. 1. Overview of the uses of insulin-secreting beta cell lines. (Green A D, et al., 2018)

Our Pancreatic Islet Cell Models

Ace Therapeutics offers a comprehensive range of pancreatic islet cell models to accelerate your diabetes research and the development of promising drugs. Our pancreatic islet cell models include:

• Primary Pancreatic Islet Cell Models
  We offer primary pancreatic islet cell models, which boast unparalleled physiological relevance. Sourced from human, rodent, and non-human primate donors, these primary islet cells faithfully recapitulate the intricate cellular composition and functional dynamics of their in vivo counterparts.
• Pancreatic Islet Cell Line Models
  We offer an islet cell line portfolio of both rodent and human origin, each having different advantages. For example, RIN, INS-1, and MIN6 cells have been well-characterized and broadly utilized models in the ability to mimic a good number of pancreatic β-cell functions, including glucose-mediated insulin secretion and critical transcription factors and signaling pathways expression.
• Immortalized Pancreatic β-Cell Line Models
  Our researchers use genetic techniques for immortalization and reversible immortalization of cells to help clients create functional, stable cell models such as NAKT-1S and BRIN-BD11. These cells have unlimited proliferative potential while retaining important functional characteristics of normal islet beta-cells.

Our Pancreatic Islet Cell-based Models

• Organoid Models of Pancreatic Islet
  Our pancreatic islet organoids are derived either from human pluripotent stem cells or from adult pancreatic progenitor cells, allowing the generation of tailored models, which can incorporate patient-specific genetic or environmental factors. These organoids display strong glucose-stimulated insulin secretion, proper hormonal profiles, and can be long-term cultured for a wide range of applications, from drug screening to personalized disease modeling.
• Organ-On-A-Chip Models for Diabetes Research
  Ace Therapeutics offers cutting-edge organ-on-a-chip model development services that integrate pancreatic islet cells with other key metabolic tissues. These advanced microfluidic platforms simulate the intricate interorgan crosstalk and metabolic homeostasis observed in the human body.

For more information on how our services can meet your specific needs, please contact us. By collaborating with Ace Therapeutics, researchers gain access to state-of-the-art models and expert support, propelling diabetes research forward.

Reference

1. Green A D, et al. (2018) Cellular models for beta-cell function and diabetes gene therapy. Acta physiologica. 222(3): e13012.

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