Cat. No.: DAB-0012353
| Product Information | |
|---|---|
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Host Species | Mouse |
| Reactivity | Human |
| Applications | WB, IHC, IF |
| Product Description | NQO1 (A180) Mouse mAb is produced by immunizing mice with purified recombinant human NQO1. |
| Format | Liquid |
| Purity | Affinity purity |
| Target Information | |
|---|---|
| Target Name | NQO1 |
| UniProt No. | P15559 |
| Gene ID | 1728 |
| Gene Description | NADH:quinone oxidoreductase 1 is a flavoprotein that catalyzes the two-electron reduction of quinones and their derivatives. This enzyme protects cells against redox cycling and oxidative stress. The expression of NQO1 is increased in liver, colon and breast tumors and non-small cell lung cancer compared with the normal tissues. Moreover, expression levels are also elevated in developing tumors, suggesting a role for NQO1 in the prevention of tumor development. Studies on NQO1 knockout mice suggest that the lack of NQO1 enzymatic activity changes intracellular redox states resulting in a reduction in apoptosis, which in turn leads to myeloid hyperplasia of bone marrow. |
| Shipping & Storage | |
|---|---|
| Shipping | Shipped at 4 °C. |
| Storage Instructions | Store at –20 °C. Do not aliquot the antibody. |
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. |
Ace Therapeutics has a team of wellknown experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
