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Cat. No.: DAB-0012323
| Product Information | |
|---|---|
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Host Species | Mouse |
| Reactivity | Human |
| Applications | IHC |
| Product Description | Monoclonal antibody is produced by immunizing animals with a synthetic peptide from human MUC2 protein, coupled to KLH. |
| Format | Liquid |
| Purity | Affinity purity |
| Target Information | |
|---|---|
| Target Name | MUC2 |
| UniProt No. | Q02817 |
| Gene Description | Mucins are a family of large glycoproteins that create the structural component of mucus. Mucus functions as a blockade against pathogenic invasion and physical injury to the respiratory, gastrointestinal, and urogenital tracts. Mucins create a protective layer for epithelial cells as either membrane-bound or secreted proteins. MUC2, or mucin-2, the main O-glycosylated protein found in mucus, is secreted by goblet cells. The structure of MUC2 contains cysteine-rich N- and C-terminal domains along with a protein core made up of heavily O-glycosylated mucin domains. The high levels of O-glycosylation along with disulfide bonding make MUC2 resistant to proteolytic cleavage. Mucin expression and glycan structure changes occur in cancers of the intestine and impact the development and progression of these cancers. The presence of MUC2 in the mucous layer of the colon helps prevent ulcerative colitis by inhibiting the invasion of bacteria. |
| Shipping & Storage | |
|---|---|
| Shipping | Shipped at 4 °C. |
| Storage Instructions | Stored at -20 °C. This product will freeze at -20 °C so it is recommended to aliquot into single-use vials to avoid multiple freeze/thaw cycles. A slight precipitate may be present, but will not interfere with antibody performance. |
| Storage Buffer | Supplied in 10 mM PBS containing 0.05% BSA and 0.05% sodium azide. Stable for 12 months when |
Ace Therapeutics has a team of experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
