Cat. No.: DAB-0012157
| Product Information | |
|---|---|
| Clonality | Monoclonal |
| Isotype | IgG2b |
| Host Species | Mouse |
| Reactivity | Human, Mouse, Rat, Monkey |
| Applications | WB, IP, IHC, IF |
| Product Description | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala174 of human IDH2 protein, as described by Kaneko et al. (2013) [8]. |
| Format | Liquid |
| Purity | Affinity purity |
| Target Information | |
|---|---|
| Target Name | IDH2 |
| UniProt No. | P48735 |
| Gene ID | 3418 |
| Gene Description | IDH2 is one of three isocitrate dehydrogenases that catalyze the oxidative decarboxylation of isocitrate to produce CO2 and α-ketoglutarate. These enzymes belong to two distinct subclasses that utilize either NAD or NADP+ as an electron acceptor. IDH2 is an NADP+-dependent isocitrate dehydrogenase expressed primarily in the mitochondria, where it also functions in the TCA cycle. Mutations in IDH2 or its cytoplasmic counterpart have been reported in glioblastoma multiforme, acute myeloid leukemia, and other malignancies. Research studies have shown that gain-of-function mutations in IDH2 can lead to the accumulation and secretion of the oncometabolite R-2-hydroxyglutarate in cancer cells. |
| Shipping & Storage | |
|---|---|
| Shipping | Shipped at 4 °C. |
| Storage Instructions | Store at –20 °C. Do not aliquot the antibody. |
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. |
Ace Therapeutics has a team of wellknown experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
