Mouse DLAT (4A4-B6-C10) Monoclonal Antibody

Mouse DLAT (4A4-B6-C10) Monoclonal Antibody

Cat. No.: DAB-0011970

Size: 20 µL Size: 100 µL Size: Customer Size
Product Information
Clonality Monoclonal
Isotype IgG1
Host Species Mouse
Reactivity Human, Monkey
Applications WB, IP, IF
Product Description Monoclonal antibody is produced by immunizing animals with a recombinant human DLAT protein.
Format Liquid
Purity Affinity purity
Target Information
Target Name DLAT
UniProt No. P10515
Gene ID 1737
Gene Description Dihydrolipoamide acetyltransferase transfers an acetyl group from pyruvate to CoA to synthesize acetyl-CoA. This protein, also known as the E2 subunit of the pyruvate dehydrogenase complex, has been implicated in the literature as the primary autoantigen in primary biliary cirrhosis. Antimitochondrial antibodies are likely formed when DLAT is exposed to the immune system in apoptotic cells of the bile duct. Research studies have shown that in some cases, cosmetics, NSAIDs, chewing gum, acetaminophen, and other compounds could trigger exposure of DLAT in sensitive individuals. The presence of AMAs is often detectable before disease diagnosis. Research studies have also shown that activation of the Toll-like receptor-3 pathway is involved in the progression from a subclinical to clinical state.
Shipping & Storage
Shipping Shipped at 4 °C.
Storage Instructions Store at –20 °C. Do not aliquot the antibody.
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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