Mouse Cox2 (E7V6C) Monoclonal Antibody

Mouse Cox2 (E7V6C) Monoclonal Antibody

Cat. No.: DAB-0011918

Size: 20 µL Size: 100 µL Size: Customer Size
Product Information
Clonality Monoclonal
Isotype IgG2a
Host Species Mouse
Reactivity Human, Mouse, Rat
Applications WB, IP
Product Description Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human Cox2 protein.
Format Liquid
Purity Affinity purity
Target Information
Target Name PTGS2
UniProt No. P35354
Gene ID 5743
Gene Description Cyclooxygenase1 and cyclooxygenase2, family members with 60% homology in humans, catalyze prostaglandin production from arachidonic acid. While Cox1 expression is constitutive in most tissues, Cox2 expression is induced by lipopolysaccharide and peptidoglycan. PGN activates Ras, leading to phosphorylation of Raf at Ser338 and Erk1/2 at Tyr204. The activation of MAP kinase signaling results in subsequent activation of IKKα/β, phosphorylation of IκBα at Ser32/36, and NF-κB activation. Finally, activation of the transcription factor NF-κB is responsible for the induction of Cox2 expression. Investigators have shown that LPS and PGN induce the clinical manifestations of arthritis and bacterial infections, such as inflammation, fever, and septic shock. Research studies have indicated that Cox1 and Cox2 may also play a role in the neuropathology of Alzheimer's disease by potentiating γ-secretase activity and β-amyloid generation.
Shipping & Storage
Shipping Shipped at 4 °C.
Storage Instructions Store at –20 °C. Do not aliquot the antibody.
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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