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Cat. No.: DIA-0230683
| Product Information | |
|---|---|
| CAS No. | 482-38-2 |
| Formula | C27H30O14 |
| Molecular Weight | 578.52 |
| SMILES | CC1OC(OC2=CC3=C(C(=C2)O)C(=O)C(=C(O3)C4=CC=C(O)C=C4)OC5OC(C)C(O)C(O)C5O)C(O)C(O)C1O |
| Product Description | Kaempferitrin has an acute lowering effect on blood glucose in diabetic rats and to stimulate the glucose uptake percentile, as efficiently as insulin in muscle from normal rats. Kaempferitrin improves insulin resistance by the activation of the classical insulin transduction pathway, and increases adiponectin secretion. Kaempferitrin exerts cytotoxic and antitumor effects against HeLa cells, the general mechanisms include cell cycle arrest in G1 phase and apoptosis via intrinsic pathway in a caspase dependent pathway. Kaempferitrin exerts immunostimulatory effects on immune responses mediated by splenocytes, macrophages, peripheral blood mononuclear cells (PBMC) and NK cells. Kaempfertrin possesses significant antiosteoporotic activity, it can significantly improve the bone mass and microarchitecture in ovariectomized (OVX) rats. Kaempferitrin has antidepressant-like effect, the effect is related to the serotonergic system, principally 5-HT1A. |
| Format & Storage | |
|---|---|
| Purity | > 99% |
| Shipping | Shipped on dry ice. |
| Storage | Powder: -20 °C, 3 years; 4 °C, 2 years In solvent: -80 °C, 6 months; -20 °C, 1 month |
| Solubility Overview | Soluble in DMSO |
Ace Therapeutics has a team of wellknown experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
