Cat. No.: DCL-001027
Product Information | |
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Parental | A549 |
Organism | Human |
Tissue | Lung |
Target Name | TSC2 |
Cell Type | Epithelial cells |
Gender | Male |
UniProt No. | P49815 |
Gene ID | 7249 |
Gene Description | In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors. |
Format | Frozen |
Growth Properties | Adherent |
Shipping & Storage | |
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Shipping | Cryopreserved on dry ice. |
Storage Instructions | Store in liquid nitrogen. |
Storage Buffer/Media | 8.7% Dimethylsulfoxide, 2% Cellulose, methyl ether |