Cat. No.: DAB-0013023
| Product Information | |
|---|---|
| Clonality | Monoclonal |
| Isotype | HuCAL Fab monovalent |
| Host Species | Human |
| Reactivity | Human |
| Product Description | The immunogens used in the generation of this antibody were: A glycated peptide, corresponding to N-terminal 9 amino acids of haemoglobin beta chain coupled to carrier proteinsPurified HbA1c. |
| Format | Liquid |
| Purity | Affinity purity |
| Target Information | |
|---|---|
| Target Name | HBB |
| UniProt No. | P68871 |
| Gene ID | 3043 |
| Gene Description | Hemoglobin is a heme-containing transport protein found primarily in the red blood cells of humans and most other vertebrates. The primary function of hemoglobin is to transport oxygen from the external environment to the body tissues. Hemoglobin also facilitates metabolic waste removal by assisting in the transport of carbon dioxide from tissues back to the respiratory organs. Mature hemoglobin is a tetrameric protein complex, with each subunit containing an oxygen-binding heme group. Multiple isoforms of hemoglobin exist, which vary in relative abundance depending on developmental stage. Adult hemoglobin is comprised of two α subunits and two β subunits and is the predominant hemoglobin found in red blood cells of children and adults. Fetal hemoglobin contains two α subunits and two γ subunits and is the predominant isoform found during fetal and early postnatal development. Mutations that alter the structure or abundance of specific globin subunits can result in pathological conditions known as hemoglobinopathies. One such disorder is sickle cell disease, which is characterized by structural abnormalities that limit the oxygen carrying capacity of red blood cells. By contrast, thalassemia disorders are characterized by deficiencies in the abundance of specific hemoglobin subunits. Clinical treatments that are designed to alter the expression of specific hemoglobin subunits can be used to treat hemoglobinopathies. |
| Shipping & Storage | |
|---|---|
| Shipping | Shipped at 4 °C. |
| Storage Instructions | This product is shipped at ambient temperature. It is recommended to aliquot and store at -20 °C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8 °C for short term use (up to 4 weeks) and store the remaining aliquots at -20 °C. Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. |
| Storage Buffer | Phosphate buffered saline 0.01% Thiomersal |
