Cat. No.: DCL-001144
Product Information | |
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Parental | A549 |
Organism | Human |
Tissue | Lung |
Target Name | FOXA2 |
Cell Type | Epithelial cells |
Gender | Male |
UniProt No. | Q9Y261 |
Gene ID | 3170 |
Gene Description | Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. |
Format | Frozen |
Growth Properties | Adherent |
Shipping & Storage | |
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Shipping | Cryopreserved on dry ice. |
Storage Instructions | Store in liquid nitrogen. |
Storage Buffer/Media | 8.7% Dimethylsulfoxide, 2% Cellulose, methyl ether |