Ace Therapeutics is one of the leading companies providing diabetes animal models for researchers worldwide. We provide comprehensive preclinical capabilities from animal model development to reproduction, trait identification, and phenotype analysis.

Understanding the Complexities of Diabetes

Diabetes is a poly-faceted disease involving most organs and systems in the body, hence the main difficulty when modeling this trait in an animal. From dysregulation of glucose homeostasis to micro- and macrovascular complications, diabetes pathogenesis involves an extremely complex interplay between genetic, metabolic, and environmental factors. An accurate recapitulation of this intricate web of pathological processes in an animal model is key to translating laboratory findings into effective therapies.

How Do We Validate Animal Models of Diabetes?

• Face Validity
  Face validity refers to the degree to which an animal model replicates the characteristic symptoms and signs of a human disease. In diabetic models, we verify the disease relevance of the model by confirming their similarity to human diseases in metabolic abnormalities, glucose homeostasis, and other symptoms.
• Predictive Validity
  Predictive validity assessment evaluates how well an animal model can be used to predict currently unknown aspects of the disease in humans. We help clients verify the correlation between the treatment results observed in the diabetes model and those seen in clinical trials.
• Construct Validity
  We help clients assess how well the mechanisms used to induce the diabetes phenotype in the animal model reflect the currently understood etiology and pathophysiology of the human condition. This ensures that the underlying biological dysfunctions in the diabetes animal model align with those observed in the clinical setting.

Our Diabetic Animal Model Validation Services

Our comprehensive animal model validation services leverage state-of-the-art technologies and rigorous scientific methods to ensure that the models employed by our clients faithfully recapitulate the key hallmarks of diabetes.

• Glucose Tolerance Tests
  We use these tests to evaluate the mouse's ability to regulate blood glucose levels in response to a glucose challenge, providing insights into insulin sensitivity and pancreatic function.
• Insulin Tolerance Tests
  This test is utilized to measure the response of the animal models to exogenous insulin, thereby allowing the assessment of insulin resistance.
• Fasting Blood Glucose Measurement
  The test is employed for the longitudinal monitoring of the level of fasting blood glucose as an indicative parameter for the development and progression of hyperglycemia.
• HbA1c Measurement
  The test is utilized to assess HbA1c levels as an indicative parameter of long-term glycemic control.
• Lipid Profile Analysis
  Dyslipidemia associated with diabetes is diagnosed by the determination of serum triglycerides and cholesterol among other lipid parameters.
• Insulin Secretion and Sensitivity Assays
  We use isolated pancreatic islets for static or dynamic insulin secretion assays. Besides, we perform hyperinsulinemic-euglycemic clamp studies, which can directly measure insulin sensitivity.
• Diabetes Complications Assessments
  We assess neuropathy, nephropathy, and cardiovascular dysfunction by functional and histopathological analysis.
• Responsiveness to Antidiabetic Drugs
  We test the animal model's response to standard-of-care diabetes medications to assess its predictive validity.

We believe that by continuing to provide the research community with animal models that accurately reflect the complexity of diabetes and its complications, we will be further empowering innovative therapies to quicken the pace of discovery in this important area of inquiry. Contact us today for more information on our diabetic animal model validation services.

Reference

1. Martín-Carro B, et al. (2023) Experimental models to study diabetes mellitus and its complications: limitations and new opportunities. International Journal of Molecular Sciences. 24(12): 10309.

• Spontaneous Models of Diabetes Mellitus
• Diet-Induced Diabetes Models
• Surgically Induced Diabetic Models
• Chemically Induced Diabetes Models
• Genetically Engineered Diabetes Models
• In Vivo Modeling of Diabetes Complications

• Mouse Models
• Assay Kits
• Antibodies
• Cell Lines & Lysates
• Proteins & Peptides
• Inhibitors & Activators