Cat. No.: DMM-001005
| Status | Age | Sex |
|---|---|---|
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| Product Overview | |
|---|---|
| Model Description | An intronic G-to-T transversion in this allele created a donor splice site that causes abnormal splicing and the inclusion of 106 nt of intronic sequence in the transcript, leading to premature termination of the long cellular domain of the Ob-Rb splice form and loss of its signal transducing function. |
| Strain Name | B6.BKS(D)-Leprdb/J |
| Background Strain | B6.BKS |
| SPF | Yes |
| Research Application | Leptin resistance; insulin resistance; obesity; and type 2 diabetes. |
| Target Information | |
|---|---|
| Target Name | Lepr |
| Synonyms | Leprb, LEPROT, leptin receptor gene-related protein, Modb1, obese-like, obl, Obr, OB-RGRP |
| Gene ID | 16847 |
