CEP-32496

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Cat. No.: DIA-0231093

Size: 50 mg Size: 500 mg Size: Customer Size

Product Information
CAS No.	1188910-76-0
Formula	C₂₄H₂₂F₃N₅O₅
Molecular Weight	517.46
SMILES	COC1=CC2=NC=NC(=C2C=C1OC)OC3=CC(=CC=C3)NC(=O)NC4=NOC(=C4)C(C)(C)C(F)(F)F
Product Description	CEP-32496 is a highly potent inhibitor of BRAF(V600E/WT) and c-Raf with Kd of 14 nM/36 nM and 39 nM, also potent to Abl-1, c-Kit, Ret, PDGFRβ and VEGFR2, respectively insignificant affinity for MEK-1, MEK-2, ERK-1 and ERK-2. Phase 1/2.

Format & Storage
Purity	> 98%
Shipping	Shipped on dry ice.
Storage	Powder: -20 °C, 3 years; 4 °C, 2 years In solvent: -80 °C, 6 months; -20 °C, 1 month
Solubility Overview	Soluble in DMSO

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