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Cat. No.: DMM-001193
| Status | Age | Sex |
|---|---|---|
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| Product Overview | |
|---|---|
| Model Description | The Cacna1a gene is located on mouse chromosome 8. Forty seven exons are identified, with the ATG start codon in exon 1 and the TAA stop codon in exon 47. Exon 3 will be selected as target site. Cas9 and gRNA will be co-injected into fertilized eggs for KO mouse production. |
| Strain Name | C57BL/6J-Cacna1aem1 |
| Background Strain | C57BL/6J |
| SPF | Yes |
| Genetic Modification | Conventional knockout |
| Research Application | Diabetes |
| Sperm Quality Evaluation | Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability. Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch. |
| Target Information | |
|---|---|
| Target Name | Cacna1a |
| Synonyms | APCA, BI, Caca1a, Cacn, Cacnl1a4, Cav2.1, Ccha, Ccha1a, EA2, FHM, HPCA, MHP, MHP1, SC, SCA6, al, alpha1A, la, nmf35, nmf352, rkr, s, smrl, tg |
| Gene ID | 12286 |
Ace Therapeutics has a team of experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
