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Cat. No.: DIA-0243028
| Product Information | |
|---|---|
| CAS No. | 1001100-69-1 |
| Synonyms | HE 3286; NE-3107 |
| Formula | C21H30O3 |
| Molecular Weight | 330.46 |
| SMILES | O[C@@H]1[C@@]2([H])[C@@]3([H])[C@@]([C@@](C#C)(O)CC3)(CC[C@]2([H])[C@]4(C)C(C[C@@H](O)CC4)=C1)C |
| Target | NF-κB |
| Product Description | Bezisterim (HE 3286; NE-3107) is a synthetic derivative of a natural anti-inflammatory steroid, β-AET. Bezisterim is an orally active partial NF-κB inhibitor. HE3286 reduces proinflammatory signals, including IL-6 and matrix metallopeptidase 3. Bezisterim freely penetrates the blood brain barrier in mice. Bezisterim can be used for the research of the ulcerative colitis, arthritis, experimental autoimmune encephalomyelitis. Bezisterim is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. |
| Format & Storage | |
|---|---|
| Format | Solid |
| Color | Off-white to light yellow |
| Purity | ≥95.0% |
| Shipping | Room temperature in the continental U.S. Other areas may vary. |
| Storage | In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Solubility Overview | Soluble in DMSO |
Ace Therapeutics has a team of experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
