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Cat. No.: DIA-0231359
| Product Information | |
|---|---|
| CAS No. | 781658-23-9 |
| Synonyms | (2S,3R)-2-Amino-4-hydroxy-3-methylpentanoic acid |
| Formula | C6H13NO3 |
| Molecular Weight | 147.17 |
| SMILES | CC(O)C(C)C(N)C(O)=O |
| Target | NFkB |
| Product Description | 4-Hydroxyisoleucine has beneficial effects on low-grade inflammation, it can reverse the insulin resistance by the activation of AMPK and suppression of SOCS-3 coimmunoprecipitation with both the IR-β subunit as well as IRS- 4-Hydroxyisoleucine acts to improve insulin resistance by promoting mitochondrial biogenesis in high fructose diet fed STZ induced diabetic rats. 4-Hydroxyisoleucine could remarkably improve high glucose-induced IR in 3T3-L1 adipocytes; could inhibit the secretion of TNF-alpha. 4-Hydroxyisoleucine has antidyslipidemic and antihyperglycemic effects. 4-Hydroxyisoleucine shows antidepressant-like effects in animal models of depression by brain serotonin turnover enhancement. |
| Format & Storage | |
|---|---|
| Purity | > 98% |
| Shipping | Shipped on dry ice. |
| Storage | Powder: -20 °C, 3 years; 4 °C, 2 years In solvent: -80 °C, 6 months; -20 °C, 1 month |
| Solubility Overview | Soluble in DMSO |
Ace Therapeutics has a team of experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
