YM-244769 di hydrochloride
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YM-244769 di hydrochloride

Cat. No: CDIA-1170
CAS. No.: 1780390-65-9
Size: 50 mg
Price: Inquiry
Product Details
Formula C26H24Cl2FN3O3
Molecular Weight 516.39
Appearance Solid
Purity 99.02%
Smiles String O=C(C1=CC=C(OC2=CC=C(OCC3=CC=CC(F)=C3)C=C2)N=C1)NCC4=CC=CC(N)=C4.Cl.Cl
Storage & Handling
Shipping Room temperature.
Storage 4 °C, sealed storage, away from moisture *In solvent : -80 °C, 6 months; -20 °C, 1 month (sealed storage, away from moisture)

Description

YM-244769 dihydrochloride is a potent, selective and orally active Na+/Ca2+ exchanger (NCX) inhibitor. YM-244769 dihydrochloride preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca2+ entry mode), with IC50s of 18 nM and 50 nM, respectively. YM-244769 dihydrochloride efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 dihydrochloride can also increase urine volume and urinary excretion of electrolytes in mice.

! For research use only. Not intended for any clinical use.