YF-452
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YF-452

Cat. No: CDIA-1799
CAS. No.: 1951466-83-3
Size: 50 mg
Price: Inquiry
Product Details
Formula C24H26BrN3O
Molecular Weight 452.39
Smiles String BrC1=CC=C(CN(C2=C3C=CC=C2)C4=C3CCN(C4)C(CN5CCCC5)=O)C=C1
Storage & Handling
Shipping Room temperature.
Storage Please refer to the instruction manual.

Description

YF-452 is a potent inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2). YF-452 remarkably inhibits the migration, invasion and tube-like structure formation of human umbilical vein endothelial cells (HUVECs) with little toxicity. YF-452 inhibits VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal regulated kinase (ERK), focal adhesion kinase (FAK) and Src. YF-452 is a potential antiangiogenic agent candidate for cancer research.

! For research use only. Not intended for any clinical use.