Yangambin

Product Details
Formula	C24H30O8
Molecular Weight	446.49
Appearance	Solid
Purity	≥98.0%
Smiles String	COC1=C(OC)C(OC)=CC([[email protected]]2OC[[email protected]]3([H])[[email protected]@H](C4=CC(OC)=C(OC)C(OC)=C4)OC[[email protected]@]32[H])=C1

Storage & Handling
Shipping	Room temperature.
Storage	4 °C, protect from light *In solvent : -80 °C, 6 months; -20 °C, 1 month (protect from light)

Yangambin, a furofuran lignan, is already isolated from plants such as member of the Annonaceae family, including species of the genus Rollinia: R. pickeli, R. exalbidaand R. mucosa, as well from the Magnolia biondii. Yangambin, a selective PAF receptor antagonist, inhibits Ca2+ influx through voltage-gated Ca2+ channels, leading to the reduction in [Ca2+]i in vascular smooth muscle cells and consequent peripheral vasodilation. Yangambin exhibits the antiallergic activity against β-hexosaminidase release with an IC50 of 33.8 μM and for anti-inflammatory activity with an IC50 of 37.4 μM.

! For research use only. Not intended for any clinical use.