TK-129

Product Details
Formula	C15H23N5O2
Molecular Weight	305.38
Appearance	Solid
Purity	≥98.0%
Smiles String	O=C(N[[email protected]]1CN(C(C2=NNC(C(C)C)=C2)=O)CC1)NC3CC3

Storage & Handling
Shipping	Room temperature.
Storage Powder	-20 °C/3 years

TK-129 is an orally active, low-toxicity, potent KDM5B inhibitor (with high affinity; IC50=44 nM). TK-129 exerts cardioprotective effects by inhibiting KDM5B and blocking the KDM5B-associated Wnt pathway. TK-129 reduces ang II-induced activation of cardiac fibroblasts in vitro and reduces isoprenaline-induced myocardial remodelling and fibrosis in vivo. TK-129 can be used in studies of cardiovascular disease.

! For research use only. Not intended for any clinical use.