T0901317

Cat. No: CDIA-0048

CAS. No.: 293754-55-9

Size: 1 mg

Price: Inquiry

Product Details
Formula	C17H12F9NO3S
Molecular Weight	481.33
Appearance	Solid
Purity	99.89%
Smiles String	OC(C(F)(F)F)(C(F)(F)F)C1=CC=C(N(CC(F)(F)F)S(C2=CC=CC=C2)(=O)=O)C=C1

Storage & Handling
Shipping	Room temperature.
Storage Powder	-20 °C/3 years, 4 °C/2 years

Description

T0901317 is an orally active and highly selective LXR agonist with an EC50 of 20 nM for LXRα. T0901317 activates FXR with an EC50 of 5 μM. T0901317 is RORα and RORγ dual inverse agonist with Ki values of 132 nM and 51 nM, respectively. T0901317 induces apoptosis and inhibits the development of atherosclerosis in low-density lipoprotein (LDL) receptor-deficient mice.

! For research use only. Not intended for any clinical use.