SCH79797 di hydrochloride
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SCH79797 di hydrochloride

Cat. No: CDIA-0353
CAS. No.: 1216720-69-2
Size: 1 mg
Price: Inquiry
Product Details
Formula C23H27Cl2N5
Molecular Weight 444.40
Appearance Solid
Purity 99.91%
Smiles String Cl[H].Cl[H].NC1=NC(NC2CC2)=NC3=CC=C(N(CC4=CC=C(C(C)C)C=C4)C=C5)C5=C31
Storage & Handling
Shipping Room temperature.
Storage 4 °C, sealed storage, away from moisture *In solvent : -80 °C, 6 months; -20 °C, 1 month (sealed storage, away from moisture)

Description

SCH79797 dihydrochloride is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. SCH79797 dihydrochloride inhibits binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 dihydrochloride inhibits thrombin-induced platelet aggregation with an IC50 of 3 μM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects, and limits myocardial ischemia/reperfusion injury in rat hearts. SCH79797 dihydrochloride also potently prevents PAR1 activation in vascular smooth muscle cells, endothelial cells, and astrocytes.

! For research use only. Not intended for any clinical use.