RWJ-56110

Cat. No: CDIA-1748

CAS. No.: 252889-88-6

Size: 50 mg

Price: Inquiry

Product Details
Formula	C41H43Cl2F2N7O3
Molecular Weight	790.73
Smiles String	O=C(N[[email protected]](C(NCC1=CC=CC=C1)=O)CCN)[[email protected]@H](NC(NC2=CC3=C(C=C2)C(CN4CCCC4)=CN3CC5=C(Cl)C=CC=C5Cl)=O)CC6=CC=C(F)C(F)=C6

Storage & Handling
Shipping	Room temperature.
Storage	Please refer to the instruction manual.

Description

RWJ-56110 is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 inhibits the aggregation of human platelets induced by both SFLLRN-NH2 (IC50=0.16 μM) and thrombin (IC50=0.34 μM), quite selective relative to U46619 (HY-108566). RWJ-56110 inhibits angiogenesis and blocks the formation of new vessels in vivo. RWJ-56110 induces cell apoptosis.

! For research use only. Not intended for any clinical use.