RWJ-56110 di hydrochloride
Online Inquiry
* Please note that all of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

RWJ-56110 di hydrochloride

Cat. No: CDIA-1026
CAS. No.: 2387505-58-8
Size: 5 mg
Price: Inquiry
Product Details
Formula C41H45Cl4F2N7O3
Molecular Weight 863.65
Appearance Solid
Purity 99.54%
Smiles String O=C(N[[email protected]](C(NCC1=CC=CC=C1)=O)CCN)[[email protected]@H](NC(NC2=CC3=C(C=C2)C(CN4CCCC4)=CN3CC5=C(Cl)C=CC=C5Cl)=O)CC6=CC=C(F)C(F)=C6.[H]Cl.[H]Cl
Storage & Handling
Shipping Room temperature.
Storage 4 °C, sealed storage, away from moisture and light *In solvent : -80 °C, 6 months; -20 °C, 1 month (sealed storage, away from moisture and light)

Description

RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride inhibits the aggregation of human platelets induced by both SFLLRN-NH2 (IC50=0.16 μM) and thrombin (IC50=0.34 μM), quite selective relative to U46619 (HY-108566). RWJ-56110 dihydrochloride blocks angiogenesis and blocks the formation of new vessels in vivo. RWJ-56110 dihydrochloride induces cell apoptosis.

! For research use only. Not intended for any clinical use.