Ro 31-8220 mesylate

Cat. No: CDIA-0235

CAS. No.: 138489-18-6

Synonyms: Ro 31-8220 methanesulfonate; Bisindolylmaleimide IX mesylate

Size: 1 mg

Price: Inquiry

Product Details
Formula	C26H27N5O5S2
Molecular Weight	553.65
Appearance	Solid
Purity	99.28%
Smiles String	NC(SCCCN1C=C(C2=C(C3=CN(C)C4=C3C=CC=C4)C(NC2=O)=O)C5=C1C=CC=C5)=N.CS(=O)(O)=O

Storage & Handling
Shipping	Room temperature.
Storage	4 °C, sealed storage, away from moisture *In solvent : -80 °C, 6 months; -20 °C, 1 month (sealed storage, away from moisture)

Description

Ro 31-8220 mesylate is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC50s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7.

! For research use only. Not intended for any clinical use.