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Recombinant Rat IL-6 Protein
Cat. No : CDRP-01267
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| Target Information | |
|---|---|
| Target Name | IL-6 |
| Synonyms | Interleukin-6; IL6; Il-6 |
| UniProt ID | Q9Y336 |
| Accession | NP_036721.1 |
| Product Details | |
|---|---|
| Expression Host | HEK293 Cells |
| Species | Rat |
| Tag | C-His |
| Molar Mass | 24 kDa |
| Sequence | Met 1-Arg 788 |
| Background |
|---|
| Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells. |
| Properties | |
|---|---|
| Purity | >95% as determined by reducing SDS-PAGE. |
| Formulation | Lyophilized from sterile PBS, pH7.4, 5% trehalose, 5% mannitol, 0.01% tween-80. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months. |
! For research use only. Not intended for any clinical use.