Recombinant Rat CLP1/COLEC12 Protein (His Tag)
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Recombinant Rat CLP1/COLEC12 Protein (His Tag)

Cat. No : CDRP-01231
size:
Target Information
Target Name CLP1/COLEC12
Synonyms Clp1; Nsr2; COLEC12
UniProt ID Q9QUM4
Accession Q4V885
Product Details
Expression Host Baculovirus-Insect Cells
Species Rat
Tag N-His
Molar Mass 72.4 kDa
Sequence Lys 30-Ser 229
Background
CLP1, also known as COLEC12, is a scavenger receptor that displays several functions associated with host defense. It contains 1 C-type lectin domain and 3 collagen-like domains. CLP1 is strongly expressed in placenta and moderately expressed in heart, skeletal muscle, small intestine and lung. It promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. CLP1 mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. It binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. It binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). CLP1 may also play a role in the clearance of amyloid beta in Alzheimer disease.
Properties
Purity >95% as determined by reducing SDS-PAGE.
Formulation Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH8.0.
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months.

! For research use only. Not intended for any clinical use.