Recombinant Mouse Tie2 Protein (aa 770-1122, GST & His Tag) (Active)
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Recombinant Mouse Tie2 Protein (aa 770-1122, GST & His Tag) (Active)

Cat. No : CDRP-01147
size:
Target Information
Target Name Tie1
Synonyms CD202B; TIE-2; TIE2; VMCM; VMCM1
UniProt ID Q96PD4
Accession Q02858
Product Details
Expression Host Baculovirus-Insect Cells
Species Mouse
Tag N-His-GST
Molar Mass 68.2kDa
Sequence Lys 33-Glu 262
Application Functional ELISA
Background
TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play critical roles in vascular maturation, maintenance of integrity and remodeling. Targeted mutagenesis of both Tek and its agonistic ligand, Angiopoietin-1, result in embryonic lethality, demonstrating that the signal transduction pathways mediated by this receptor are crucial for normal embryonic development. TEK signaling is indispensable for the development of the embryonic vasculature and suggests that TEK signaling may also be required for the development of the tumor vasculature.
Properties
Purity >95% as determined by reducing SDS-PAGE.
Formulation Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH8.0.
Reconstitution Please refer to the printed manual for detailed information.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 °C. Reconstituted protein solution can be stored at 4-8 °C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 °C for 3 months.

! For research use only. Not intended for any clinical use.